A cell cycle-dependent mechanism of renal tubule epithelial cell hypertrophy.
نویسنده
چکیده
The response of renal epithelial cells to injury can include hyperplasia (increase in cell number), apoptosis (cell death), antiproliferation (growth arrest), or hypertrophy (cells physically enlarge). Examining cell size and the protein:DNA ratio can differentiate between the growth response patterns, but it is proposed that the degree of activation of cyclin D kinase in the late G1 phase of the cell cycle differentiates between hyperplasia and hypertrophy.
منابع مشابه
Cell cycle regulatory proteins in renal disease: role in hypertrophy, proliferation, and apoptosis.
The response to glomerular and tubulointerstitial cell injury in most forms of renal disease includes changes in cell number (proliferation and apoptosis) and cell size (hypertrophy). These events typically precede and may be responsible for the accumulation of extracellular matrix proteins that leads to a decrease in renal function. There is increasing evidence showing that positive (cyclins a...
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ورودعنوان ژورنال:
- Kidney international
دوره 56 4 شماره
صفحات -
تاریخ انتشار 1999